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骨髓移植后的康复与通常护理相比,以改善患者的治疗结果 (REBOOT):随机对照试验的协议

Linda Denehy^1,2,3, Shaza Abo^4,5, Christopher Swain⁴

¹Department of Physiotherapy, The University of Melbourne, 161 Barry Street, Parkville, VIC, 3010, Australia. l.denehy@unimelb.edu.au.

|March 24, 2025

概括

这项研究评估了一项多学科的康复计划,用于骨髓移植后的血液癌症患者. 该REBOOT试验旨在改善这些患者的身体功能和生活质量.

科学领域:

在瘤学瘤学.
康复医学康复医学康复医学
临床试验临床试验

背景情况:

血液癌症影响全球超过130万,骨髓移植率不断增加.
骨髓移植恢复涉及严重的副作用,影响身体功能和生活质量.
关于移植后多学科康复有效性的证据有限.

研究的目的:

评估为期八周的多学科康复干预对血液癌症患者骨髓移植后身体功能的影响.
使用EORTC QLQ-C30身体功能领域,将干预组与通常的护理进行比较.
调查二次结果,包括疲劳,体力活动和营养状况.

主要方法:

一个多站点,随机对照试验 (RCT) 涉及170名参与者后异构或自身骨髓移植.
干预组接受了远程健康运动,饮食咨询,蛋白质补充剂和家庭体育活动计划.
主要结局:患者报告的身体功能 (EORTC QLQ-C30). 二次结果:疲劳,身体活动,虚弱,身体组成和营养.

主要成果:

摘要不包含结果,因为该研究可能正在进行或最近开始.
进一步的分析将包括健康经济和过程评估.
该REBOOT试验已注册 (ACTRN12622001071718) 并旨在提供强有力的证据.

结论:

该REBOOT试验将为骨髓移植后康复的有限知识基础提供严格的RCT证据.
如果有效,这种多学科的方法可以整合到标准的护理途径.
这项研究解决了改善血液癌症幸存者的康复支持的关键需求.

关键词:

改变行为行为.进行骨髓移植.癌症癌症癌症癌症运动运动运动.血液学血液学血液学营养营养营养营养营养物理功能物理功能康复康复康复康复进行干细胞移植.远程医疗服务是远程医疗服务.

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