相关实验视频
Updated: May 20, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.2K
独立和联合的空气污染物暴露与血液细胞介导的功能障碍有关
Huanhuan Wang1,2, Zhongcheng Li2, Jing Wang3
1School of Laboratory Medicine, Chengdu Medical College, Chengdu, 610500, Sichuan, People's Republic of China.
Scientific reports
|March 24, 2025
概括
空气污染暴露与血清尿酸 (UA) 水平的升高和血液细胞数量的改变有关. 周围单细胞数量调解了这种关系,这表明它在空气污染中发挥了作用.
科学领域:
- 环境健康 环境健康
- 血液学 血液学 血液学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 空气污染是已知的高尿血症风险因素,但机制尚不清楚.
- 了解空气污染物和尿酸之间的联系对于公共卫生至关重要.
- 以前的研究表明存在相关性,但缺乏详细的机制性见解.
研究的目的:
- 调查联合空气污染物 (CAPs) 的每日暴露剂量与血清尿酸 (UA) 水平之间的关系.
- 探索外围血液细胞计数在调解空气污染对UA水平影响中的作用.
- 通过UA升高来阐明空气污染对功能障碍的潜在影响.
主要方法:
- 对233个匿名健康和城市空气污染物数据集的回顾性分析.
- 根据每天1.22毫克的CAPs值,将个人分为低暴露 (LEG) 和高暴露 (HEG) 组.
- 多变量调整的线性回归和调解效应模型来分析关联和调解作用.
主要成果:
- 在HEG中观察到更高的外周血细胞计数 (WBC,eosinophils,basophils,monocytes,RBCs) 和较低的血小板计数.
- 与LEG相比,HEG的血清UA水平显著更高.
- 周围单细胞计数被确定为空气污染物暴露和血清UA水平之间的剂量反应关系的关键调解者.
结论:
- 暴露于空气污染可能会通过改变血细胞和诱导低级炎症来提高血清UA水平.
- 周围单细胞在空气污染和高尿血症之间的关联中起着调解作用.
- 这种机制突出了空气污染可能增加功能障碍风险的潜在途径.
相关概念视频
01:20Renal Corpuscle
1.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.4K
01:17Drug Elimination by Renal Route: Glomerular Filtration
5.3K
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...
5.3K
01:17Factors Affecting Renal Clearance: Renal Impairment
44
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
44
01:11Renal Failure: Dose Adjustments
50
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
50
01:31Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
150
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
150
01:28Renal Drug Excretion: Tubular Secretion
100
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
100