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在加拿大大不列颠哥伦比亚省使用围产期ADHD刺激药物的流行趋势和模式

Amanda Nitchske^1,2, Ali Salmanpour¹, Paramdeep Kaur¹

¹Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

Pharmacoepidemiology and drug safety

|March 24, 2025

概括

怀孕期间使用ADHD兴奋剂药物的数量显著增加,大多数人停止治疗. 需要进一步研究药物对父母和儿童健康的风险和益处.

科学领域:

生殖健康生殖健康
神经科学是一个神经科学.
公共卫生公共卫生

背景情况:

成年女性的注意力缺陷/多动症 (ADHD) 诊断和兴奋剂药物使用正在增加.
围产期心理健康管理需要了解药物趋势.

研究的目的:

描述在不列颠哥伦比亚省怀孕期间使用ADHD兴奋剂药物的流行趋势.
为了确定围产期ADHD兴奋剂药物使用的特征和模式.

主要方法:

利用 899,679 个怀孕 (2000-2021) 的基于人口的相关行政数据.
定义的ADHD兴奋剂的使用由处方德克斯特罗-/安非他胺,甲基,或lisdexamfetamine.
分析了从怀孕前1年到产后1年的流行趋势,使用者特征和药物使用模式.

主要成果:

产前多动症兴奋剂药物使用量增加了11倍 (0.4到4.3/1000例怀孕),主要是由于德克斯特罗/安非他胺.
使用率在所有年龄组都上升,在20岁以下的年龄组中最高;使用者更有可能是无卵子,收入较低,高血压,BMI较高,吸烟,使用其他精神药物,并进行剖腹产.
77%的人在怀孕前/怀孕期间停止服用药物;产后使用仍然比怀孕前水平低45%.

结论:

怀孕期间使用ADHD兴奋剂药物的显著增加需要进一步调查.
高停药率凸显了理解药物安全性和药物对父母和儿童福祉有效性的关键差距.
更多的研究对于权衡围产期兴奋剂药物的风险和益处至关重要.

关键词:

注意力缺陷/多动症障碍 (ADHD)药物使用研究药物使用研究怀孕怀孕怀孕怀孕怀孕兴奋剂是一种刺激剂.

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