终身体重模式,体重减轻和细胞癌亚型
Zhengyi Deng1, Chiyuan Amy Zhang1, Justin X Moore2
1Department of Urology, Stanford University School of Medicine, Palo Alto, California, USA.
Cancer
|March 24, 2025
概括
在一生中保持健康的体重指数 (BMI) 对于降低细胞癌 (RCC) 风险至关重要. 成年人体重增加增加了RCC危险,而体重减轻可能会降低它.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 中年肥胖是细胞癌 (RCC) 的已知危险因素.
- 关于终身体重指数 (BMI) 模式与RCC风险 (包括特定亚型) 之间的关联存在有限的数据.
- 了解这些长期关联对于预防策略至关重要.
研究的目的:
- 调查一生BMI轨迹,累积体重过剩和BMI变化与患细胞癌 (RCC) 的风险之间的关联.
- 为了检查这些协会在不同的RCC亚型,包括透明细胞 (ccRCC),乳头细胞 (pRCC),和染色体 (chRCC).
主要方法:
- 利用了美国国家卫生研究院-美国退休人员协会饮食和健康研究 (n=204,364) 的数据.
- 评估了终身体重模式,包括多个年龄段的BMI,BMI轨迹,累计暴露于超重 (加权年超重/肥胖 - WYO) 和BMI变化.
- 采用Cox比例危险模型来估计RCC的整体,侵略性,致命性和特定组织学亚型的危险比率 (HRs) 和95%置信区间 (CI).
主要成果:
- 所有测量年龄段的更高的BMI与整体RCC和大多数亚型的风险增加相关,除了染色恐惧RCC.
- 成年人体重增加轨迹和较高的累积接触过重 (WYO) 与整体,攻击性,致命和清晰细胞RCC的风险增加有关.
- 显著的BMI降低 (≥10%),特别是在50岁后,与降低RCC风险有关.
结论:
- 终身超重和成年期体重增加与患细胞癌 (RCC) 的风险更高,特别是清细胞亚型.
- 减肥表明有可能减轻RCC风险.
- 这些发现强调了体重管理在整个生命周期中对于RCC预防的重要性.
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