接受全源造血干细胞移植的儿童的维生素D状况:一项前性探索性研究
Janne Anita Kvammen1,2, Rut Anne Thomassen1,2, Jochen Buechner3
1Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway.
Journal of pediatric gastroenterology and nutrition
|March 24, 2025
概括
接受全源造血干细胞移植 (HSCT) 的儿童面临高维生素D缺乏风险,特别是在移植后的早期. 增加维生素D摄入量对这些患者至关重要,需要监测和补充.
科学领域:
- 儿科血液学 儿科血液学
- 移植免疫学 移植免疫学
- 营养科学 营养科学
背景情况:
- 同源性造血干细胞移植 (HSCT) 携带着重要的营养风险.
- 维生素D的状态和摄入量是患者康复和HSCT后结果的关键因素.
研究的目的:
- 为了评估维生素D状态 (25(OH) D和1,25(OH) 2D) 和儿科HSCT接受者的摄入量.
- 为了比较HSCT患者和健康儿童之间的维生素D水平和摄入量.
- 确定接受HSCT的儿童中维生素D缺乏的患病率和时间.
主要方法:
- 预期的观察性研究设计.
- 在基线,HSCT后3个月和1年内测量血清25 ((OH) D和1,25 ((OH) 2D.
- 维生素D摄入量的饮食评估,使用3个月和1年的4天食物记录.
主要成果:
- 与健康儿童 (2%) 相比,HSCT患者在基线 (36%) 和3个月 (24%) 的维生素D缺乏的患病率更高.
- 在移植后的早期访问中,在HSCT患者中观察到的较低的中位数1,25...OH) 2D水平.
- 3个月 (18.1微克/天) 和1年 (25微克/天) 的HSCT患者的维生素D摄入量明显高于对照组 (5.3微克/天).
结论:
- 接受HSCT的儿童具有较高的维生素D缺乏风险,特别是在移植后的早期.
- 尽管摄入量增加,但维生素D缺乏症可能会持续,这表明HSCT患者的需求更高.
- 定期监测和适当的维生素D补充对于儿科HSCT接受者至关重要.
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