血清生物标志物和基因多态性在COPD和COPD与T2DM患者中的血清生物标志物
Seema Singh1, Sunita Singh2, Anuj Kumar Pandey1
1Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh 226003 India.
Indian journal of clinical biochemistry : IJCB
|March 24, 2025
概括
莱普,阿迪波涅丁和IL-8的遗传变异影响慢性阻塞性肺病 (COPD) 和2型糖尿病 (T2DM) 的风险. 特定的瘦素基因型 (TT) 与COPD患者的T2DM风险较高有关,而IL-8 (CT) 对COPD提供保护.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
背景情况:
- 炎症是慢性阻塞性肺病 (COPD) 病原发生的一个关键因素.
- 新出现的证据强调了炎症在2型糖尿病 (T2DM) 发展中的作用.
- 特别是在炎症标志物和遗传倾向方面,COPD和T2DM之间的相互作用需要进一步研究.
研究的目的:
- 在COPD和T2DM患者中,调查阿迪波涅克丁,莱普和IL-8基因多态化及其血清水平之间的关联.
- 确定特定基因变异对COPD患者T2DM风险和发展的影响.
- 为了确定潜在的遗传生物标志物来诊断和预测COPD和T2DM在受影响的个体.
主要方法:
- 一项包括500名参与者的队列研究,包括健康对照组,COPD患者和患有T2DM的COPD患者.
- 采用标准技术,对叶丁 (C/T),阿迪波涅丁 (C/G) 和IL-8 (C/T) 多态的基因定型.
- 血清中细胞因子水平 (莱普丁,阿迪波涅丁,IL-8) 通过酶相关免疫吸收试验 (ELISA) 量化.
主要成果:
- 与健康对照组相比,患有T2DM的COPD患者的血清水平显著增加了勒丁,阿迪波涅丁和IL-8 (P < 0.001).
- 在COPD患者中,瘦素"CT"基因型与患上COPD的风险增加了3.7倍,但不是T2DM.
- 叶黄素"TT"基因型显示,COPD患者患T2DM的风险显著增加2.4倍,这表明这两种疾病的风险更高.
结论:
- 瘦素"TT",脂肪素"GG"和IL-8"TT"基因型可以作为有价值的生物标志物,用于COPD和COPDT2DM的预后和诊断.
- IL-8"CT"基因型表现出对抗COPD发展的保护作用.
- 炎症标志物的遗传变异在COPD和T2DM的同时发生和进展中起着重要作用.
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
COPD: Pathogenesis and Clinical Features
218
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
218
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
39
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
39
COPD: Management Using Bronchodilators and Corticosteroids
163
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
163
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K


