天生的免疫调节纳米生物材料用于控制炎症分辨率.
Yongjiang Li1,2, Wei Chen1,2, Seyoung Koo1
1Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
概括
纳米生物材料可以调节先天免疫力以解决炎症. 本综述探讨了创新的纳米生物材料及其与免疫细胞的相互作用,用于治疗炎症性疾病,突出显示了未来的挑战.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 急性炎症反应对宿主防御至关重要,但其未解决的状态可能导致严重的疾病.
- 天生的免疫细胞 (中性粒细胞,单细胞,巨细胞,内皮细胞) 是炎症启动,放大和解决的核心.
- 调节这些免疫细胞及其相互作用为炎症状况提供了治疗机会.
研究的目的:
- 审查旨在调节天生的免疫力和减轻炎症的创新纳米生物材料.
- 总结设计纳米生物材料的策略,了解用于免疫调节的纳米生物相互作用.
- 讨论基于纳米生物材料的炎症疾病治疗的未来前景和翻译挑战.
主要方法:
- 关于纳米生物材料及其在天生的免疫力中的作用的科学文献的综述.
- 对设计针对先天免疫细胞的纳米生物材料策略的分析.
- 检查影响炎症概况的纳米生物相互作用.
- 纳米医学方法的总结,包括纳米解决药物.
主要成果:
- 纳米生物材料通过向和与先天免疫细胞相互作用,显示出显著的治疗潜力.
- 多功能纳米生物材料可以被设计为特殊调节先天免疫反应.
- 纳米化解药物,结合了亲溶解介质,在动物模型中显示出有效性.
结论:
- 纳米生物材料通过操纵先天免疫来治疗炎症性疾病提供了有希望的途径.
- 了解纳米生物相互作用是推动免疫调节纳米生物材料设计的关键.
- 克服翻译挑战对于纳米生物材料在炎症疾病治疗中的临床应用至关重要.
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