治疗急性白血病的阴影:血统切换器
Qiaoyi Zhou1,2, Ying Wang1,2
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
血统切换,急性髓性白血病 (AML) 变成急性淋巴细胞白血病 (ALL) 或相反,是一种罕见但严重的并发症. 了解其原因和改善治疗对于更好的患者结果至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 血统切换是一种罕见的现象,急性髓性白血病 (AML) 转化为急性淋巴细胞白血病 (ALL) 或相反,起源于相同的克隆.
- 像ALL一样,AML复发更为常见,受细胞遗传学,微环境和先前治疗等因素的影响.
研究的目的:
- 探索不清楚的血统切换病因,包括克隆选择,干细胞可塑性和细胞分化.
- 为了强调确认复发性白血病的共同克隆起源的诊断重要性.
- 要突出区分血统切换与其他血液性恶性瘤的必要性.
主要方法:
- 关于AML和ALL的血统切换现有文献的审查.
- 对血统切换的诊断标准的分析,重点是克隆起源.
- 评估当前的治疗策略及其对患者预后的影响.
主要成果:
- 血统切换的特点是从主要白血病的常见细胞产生复发性瘤,有时涉及克隆进化.
- 从二次白血病或慢性白血病爆发期区分分别血统切换是关键的.
- 目前针对当前血统的治疗方法提供了有限的改善;结果仍然很差,存活率低,进展迅速.
结论:
- 造血干细胞移植可以在血统切换的情况下延长存活时间.
- 根据风险调整的管理分层可能会改善早期检测和及时治疗.
- 开发高效,低毒性疗法对于改善血统切换患者的预后至关重要.
更多相关视频
06:28Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
Published on: November 10, 2023
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
相关概念视频
Lineage Commitment
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
