BGMDB:一个精心策划的数据库,将肠道微生物群失调与大脑疾病联系起来
Kai Shi1,2, Qisheng He1, Pengyang Zhao1
1College of Computer Science and Engineering, Guilin University of Technology, Guilin, China.
Computational and structural biotechnology journal
|March 24, 2025
概括
大脑疾病肠道微生物群数据库 (BGMDB) 将肠道微生物与大脑疾病联系起来. 本资源有助于理解肠-大脑通信,并开发针对神经疾病的新型微生物组向疗法.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 生物信息学是一种生物信息学.
背景情况:
- 肠道微生物群在人类健康中起着至关重要的作用,并且越来越多地与神经系统疾病有关.
- 由神经递质介导的肠-大脑通信对于大脑疾病的进展和治疗至关重要.
- 目前还缺乏详细介绍肠道微生物群与大脑疾病之间的复杂相互作用的全面资源.
研究的目的:
- 开发大脑疾病肠道微生物群数据库 (BGMDB),这是一个经过实验验证的肠道微生物群与大脑疾病关联的精心策划的存储库.
- 整合肠道微生物群的数据,大脑疾病,神经递质和遗传关联.
- 为研究人员提供一个用户友好的平台来探索肠-大脑相互作用.
主要方法:
- 策划了一个实验验证的肠道微生物群与大脑疾病之间的关系库.
- 汇编了1419个关联,609个肠道微生物群种,43个大脑疾病和184个三方相互作用的数据.
- 来自gutMGene数据库的综合遗传数据,用于探索微生物群介导的遗传关联.
- 开发了一个用户友好的界面,具有图形查询工具和浏览功能.
主要成果:
- 据BGMDB记录,609种肠道微生物群和43种脑部疾病之间有1419种关联.
- 它包括184个三方相互作用,涉及6个神经递质系统的脑疾病,神经递质和微生物群.
- 数据库整合了遗传数据,使得可以探索微生物群介导的遗传链接与脑疾病病理学.
结论:
- 该BGMDB作为一个全面的资源,以了解神经疾病的肠-大脑相互作用.
- 它促进了对肠道微生物群在脑疾病中的作用的机械洞察.
- 该数据库支持开发针对神经疾病的新型微生物向治疗策略.
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