先进的糖化终产品,代谢指标,HbA1c,和糖尿病病之间的关系
Liping Xue1, Yi Zhang1, Qiu Zhang1
1Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in endocrinology
|March 24, 2025
概括
非侵入性先进糖化终产物 (AGEs) 在2型糖尿病早期糖尿病脏病 (DN) 查方面表现有前途. 像HbA1c和BMI这样的代谢因素影响了AGE和DN进展之间的关系.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢性疾病研究研究
背景情况:
- 糖尿病病 (DN) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 早期对DN进行查对于及时干预和管理至关重要.
- 对于有效的DN检测,需要非侵入性生物标志物.
研究的目的:
- 评估非侵入性先进糖化终产品 (AGEs) 在T2DM患者早期糖尿病脏病 (DN) 查中的有用性.
- 调查代谢参数的调节作用,包括糖化血红蛋白A1c (HbA1c),在AGE和DN之间的关系中.
- 探索AGE,代谢标志物和DN发展之间的相互作用.
主要方法:
- 这是一项涉及912名T2DM患者的横截面研究.
- 糖尿病病 (DN) 通过尿中的白蛋白与肌素比率 (UACR) 进行评估.
- 使用皮肤自光技术进行高级糖化终产品 (AGEs) 的非侵入性测量;计算 AGEage (AGEs ×年龄/100).
主要成果:
- 糖尿病病 (DN) 的患病率为37.2%.
- 较高的 AGEage 与较高的 DN 患病率显著相关 (χ2 = 61.06).
- 年龄与UACR水平正相关 (β = 0.154,P<0.001),HbA1c,BMI和TyG-BMI显著缓解了这种关联,表明了复杂的相互作用.
结论:
- 非侵入性AGE检测,特别是AGEage,是T2DM早期DN查的一个有价值的工具.
- 代谢参数如HbA1c,BMI和TyG-BMI在AGE和DN之间的关系中发挥着重要作用.
- 建议针对AGE和代谢控制的综合干预措施用于T2DM患者的DN预防.
更多相关视频
06:26Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
Published on: February 14, 2020
15.2K
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
67.6K
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Overview of Carbohydrate Metabolism
619
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
619
Diabetes: Symptoms, Diagnosis, and Complications
494
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
494
Proteoglycans
3.8K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.8K
Pathophysiology of Diabetes
833
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
833
Hypoglycemia and Glucagon
143
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
143
