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在患有子宫内膜异位症的妇女中保护生育能力
Antonio La Marca, Michela Semprini1, Elisa Mastellari2
1Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
Human reproduction open
|March 24, 2025
概括
通过卵细胞玻璃化保存生育能力是患有子宫内膜异位症的女性可行的选择,为其他患者群体提供类似的结果. 然而,对于子宫内膜异位症患者的这种手术的具体指示需要进一步确定.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
背景情况:
- 子宫内膜异位症会影响多达50%的不孕女性,并且在接受辅助生殖技术 (ART) 治疗的女性中占10%.
- 卵巢内分泌瘤与卵巢储备减少密切相关,这是与子宫内膜异位症相关的不孕症的关键因素.
- 目前与子宫内膜异位症相关的不孕症的管理是复杂的,平衡了对卵巢储备的手术风险和受孕机会.
研究的目的:
- 批判性地审查有关子宫内膜异位症患者生育能力保护的文献.
- 评估卵细胞冷保存在患有子宫内膜异位症的妇女的可行性和结果.
- 确定影响子宫内膜异位症患者生育保存策略成功的因素.
主要方法:
- 使用PubMed,Scopus和Medline进行了批判性文献审查.
- 关键词包括"生育保护"",卵细胞玻璃化"",子宫内膜异位症"",子宫内膜瘤"",卵巢储备"和"体外受精".
- 审查的重点是针对子宫内膜异位症患者卵细胞冷保存的同行评审文章.
主要成果:
- 对子宫内膜异位症患者来说,卵细胞冷保存是可行的,卵细胞检索数量和试管婴儿结果与其他适应症相比相当.
- 由于子宫内膜异位症患者的卵巢储量可能减少,可能需要进行多次刺激周期.
- 影响成功的关键因素包括患者年龄,基线卵巢储备和之前的卵巢手术史.
结论:
- 患有子宫内膜异位症的妇女,特别是双边子宫内膜异位瘤或经常性卵巢手术的妇女,应被告知卵巢储备可能受到损害.
- 卵细胞冷保存对于这些患者来说是一个经过验证的,成功的技术,尽管确切的指示仍在研究中.
- 预测与子宫内膜异位症相关的不孕症和卵巢损伤严重程度仍然具有挑战性,强调需要个性化生育保护策略.
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