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多个振荡器是小鼠昼夜预期食物的基础

David E Ehichioya¹, Ishrat Masud^1,2, S K Tahajjul Taufique¹

¹Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA.

Neurobiology of sleep and circadian rhythms

|March 24, 2025

概括

动物通过两种内部体内时钟保留食物预期记忆. 一个时钟调整到食时间表,而另一个时钟保持不变,解释了为什么寻找食物的行为会持续下去.

科学领域:

时间生物学时间生物学
行为神经科学行为神经科学
动物模型动物模型

背景情况:

循环节律起器调节日常节律,使人们能够预测食物等环境线索.
动物在受限养期间表现出食物预测活性 (FAA),随着自由养消失,但在剥夺后重新出现.

研究的目的:

为了研究动物如何保留在任意养期间食物可用性的时间记忆的潜在机制.
探索不同内部振荡器在维持食物预期中的作用.

主要方法:

利用开源的Feeding Experimentation Device 3 (FED3) 来测量小鼠在寻找食物时鼻子的行为.
实施了日间限制养和随后随意养的养计划.
观察了野生类型和db/db类型的小鼠,以评估代谢条件对预期的影响.

主要成果:

小鼠在白天受限食期间以及在通常的夜间食时间显示出预期的鼻.
随着随意养,白天的鼻转移到夜间,但食物剥夺迅速恢复了白天的预期.
Db/db小鼠在摄入食物时表现出每日节律受损,但强大的食物预期,表明特定的振荡器缺陷.

结论:

数据表明,至少有两个不同的昼夜振荡器控制着食物预期.
一个振荡器的相位是灵活的,适应了供给的可用性,而第二个则保持固定.
在db/db小鼠中,柔性振荡器似乎受损,而固定振荡器保持功能.

关键词:

进行训练.额外的SCN昼夜节律起器.代谢过程中的代谢.动机动机动机操作室的操作室时间记忆时间记忆 2 型糖尿病 2 型糖尿病 db/db小鼠的使用情况

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