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门德尔随机分析确定了多部位慢性疼痛对阻塞性睡眠呼吸暂停的因果影响

Zuxing Wang¹, Lili Chen¹, Ruishi Kang²

¹Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, People's Republic of China.

Nature and science of sleep

|March 24, 2025

概括

多部位慢性疼痛 (MCP) 显著增加阻塞性睡眠呼吸暂停 (OSA) 的风险,但OSA不会导致MCP. 针对疼痛,肥胖和教育的干预措施可能会降低MCP患者的OSA风险.

科学领域:

遗传学遗传学是一个
睡眠医学睡眠医学
疼痛医学医学疼痛医学

背景情况:

观察性研究表明,阻塞性睡眠呼吸暂停 (OSA) 和慢性疼痛之间存在联系.
这种关联的因果关系证据仍未得到证实.

研究的目的:

使用孟德尔随机化 (MR) 调查多部位慢性疼痛 (MCP) 和OSA之间的潜在因果关系.
探索可修改因素在MCP-OSA协会中的调解作用.

主要方法:

利用来自大型MCP全基因组协会研究 (GWAS) 的26个独立单核酸多态 (SNPs) 作为工具变量.
使用来自FinnGen联盟 (16,761例OSA病例,201,194例对照) 的数据测试了与OSA的关联.
进行了MR分析,包括MR-Egger和加权中位数方法,以及调解分析.

主要成果:

遗传证据支持MCP作为OSA风险的预测指标;每位点MCP的增加与OSA风险增加184%有关 (OR_IVW = 1.84).
反向关联分析发现OSA对MCP没有显著的因果作用.
身体质量指数 (BMI),腰围和教育程度显著介导了MCP和OSA之间的关联.

结论:

MCP是OSA的一个可能的因果风险因素.
对疼痛管理,肥胖预防 (BMI,腰围) 和健康教育的干预措施可能会降低MCP患者的OSA风险.

关键词:

门德尔的随机化因果关系影响因果关系影响.调解的效果是调解效应.多部位慢性疼痛多部位慢性疼痛阻塞性睡眠呼吸暂停 (SOP) 的情况.

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