在大流行时代,COPD恶化,空气污染物波动和个人层面的因素
Sahar Mikaeeli1,2,3, Dany Doiron1, Jean Bourbeau1,4,5
1Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada.
概括
流行性空气污染,特别是总氧化剂 (Ox),恶化了慢性阻塞性肺病 (COPD) 的恶化. 女性性别,喘和血液中乙酸氨也被确定为COPD事件的关键风险因素.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 恶化是致病率和死亡率的主要原因.
- 流行病时代的环境变化,包括空气污染物的波动,可能会影响COPD恶化.
- 关于大流行时代空气污染物与COPD事件的关联,研究有限.
研究的目的:
- 调查大流行时代空气污染物暴露和COPD恶化之间的关联.
- 为了确定个人层面的风险因素,有助于COPD恶化在疫情期间.
主要方法:
- 利用了加拿大队列阻塞性肺病 (CanCOLD) 研究的数据,比较了大流行前和大流行期间.
- 评估了二氧化 (NO2),细颗粒物 (PM2.5),臭氧 (O3) 和总氧化剂 (Ox) 与基于症状和基于事件的恶化之间的关联.
- 使用通用估计方程 (GEE) 来估计每四分位数范围 (IQR) 的速率比率 (RRs).
主要成果:
- 在大流行期间观察到NO2,PM2.5和Ox度的显著降低.
- 基于症状和基于事件的恶化率都比大流行前更高.
- 在大流行前和大流行期间,总氧化剂 (Ox) 暴露与基于症状的恶化有关.
- 女性性别,并发性喘和血液中乙酸氨被确定为显著的个体风险因素.
结论:
- 总氧化剂 (Ox) 暴露始终与基于症状的慢性慢性病恶化有关.
- 女性性别,并发性喘和血液中埃索诺菲利亚是COPD恶化的重要危险因素.
- 了解这些关联对于在环境变化期间管理COPD至关重要.
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