辛尼塞斯菌根减少炎症,并保护BEAS-2B细胞免受LPS诱导的THP-1细胞损伤
Xiaqing Wu1,2, Xin Li2, Ying Chai1,2
1Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center, Zhengzhou, Henan, People's Republic of China.
Journal of inflammation research
|March 24, 2025
概括
科尔迪塞普斯辛内西斯提取物 (CSE) 通过抑制促炎细胞因子和氧化应激,有效降低炎症. 这项研究显示了CSE.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 科迪塞普斯 (Cordyceps sinensis) 是一种以独特的生物特性而闻名的真菌.
- 它的抗炎性潜力需要详细研究炎症调节.
研究的目的:
- 为了分析Cordyceps sinensis (CSE) 的乙醇提取物.
- 评估CSE对炎症调节的影响,包括细胞因子分泌,MMP9,Nrf2/HO-1通路和ROS.
- 在细胞模型中探索炎症损伤并分析基因表达模式.
主要方法:
- 在Cordyceps sinensis中提取乙醇.
- 在THP-1细胞上进行细胞毒性测定.
- 对促炎性细胞因子 (IL-6,TNF-α,IL-8,IL-1β) 和MMP9水平的分析.
- 对Nrf2/HO-1信号通路和活性氧物种 (ROS) 的评估.
- 用THP-1和BEAS-2B细胞进行炎症损伤评估的Transwell系统.
- 基因本体学 (GO) 和基因和基因组 (KEGG) 丰富分析的京都百科全书.
主要成果:
- 在高达1.6毫克/毫升的度下,CSE没有显示对THP-1细胞的细胞毒性.
- 在LPS诱导的THP-1细胞中,CSE显著抑制了促炎性细胞因子的细胞因子分泌.
- CSE降低了MMP9水平,并提高了抗炎 Nrf2/HO-1 途径的调节.
- CSE减轻了氧化应激诱导的炎症,并保护了BEAS-2B细胞免受炎症损伤.
- GO和KEGG分析表明CSE在免疫系统过程和炎症/抗炎基因调节中的作用.
结论:
- CSE显示出显著的抗炎和免疫调节特性.
- 这些发现支持在功能性食品和健康产品中使用CSE.
相关概念视频
T Cell Types and Functions
724
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
724
Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Inflammatory Response
1.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.7K


