儿童对口服trimethoprim-sulfamethoxazole的过敏反应:一个案例报告
Haruna Mabuchi1,2, Naoki Kajita1, Go Kusakawa1
1Division of Allergy, Tokyo Metropolitan Children's Medical Center, Fuchu, JPN.
Cureus
|March 24, 2025
概括
对trimethoprim-sulfamethoxazole (TMP-SMX) 的过敏反应很少发生,但在儿童中可能发生. 一个基细胞激活试验 (BAT) 显示出承诺作为一个比药物诱导试验 (DPT) 更安全的诊断工具,用于TMP-SMX过敏.
科学领域:
- 儿科过敏和免疫学
- 临床药理学 临床药理学
- 药物过敏症 药物过敏症
背景情况:
- trimethoprim-sulfamethoxazole (TMP-SMX) 是一个在儿科护理中广泛使用的抗生素,用于治疗感染和预防.
- 虽然通常与非直接的过敏相关,但像过敏反应这样的直接反应并不常见.
研究的目的:
- 在儿科患者中向TMP-SMX报告罕见的过敏反应病例.
- 评估基基细胞激活测试 (BAT) 的诊断效用,作为在怀疑TMP-SMX过敏时更安全的替代药物诱导测试 (DPT) 的替代方案.
主要方法:
- 一个案例报告,一个六岁的女孩在TMP-SMX给药后经历过敏反应.
- 使用TMP-SMX进行皮肤刺伤测试 (SPT).
- 进行了一次药物挑测试 (DPT).
- 使用TMP-SMX组合进行了基细胞激活试验 (BAT).
主要成果:
- 患者呈现了对TMP-SMX的过敏反应.
- 对TMP-SMX进行皮肤刺痛测试,结果为负.
- 药物诱导试验 (DPT) 证实了过敏反应.
- 对于TMP-SMX的基细胞激活试验 (BAT) 呈阳性.
结论:
- 这一案例凸显了儿童对TMP-SMX罕见的立即过敏反应的可能性.
- 基细胞激活测试 (BAT) 显示出积极的结果,与DPT相比,它可能是一个更安全的诊断工具,用于TMP-SMX过敏.
- 需要进一步的研究来验证BAT作为诊断儿童群体TMP-SMX过敏的可靠方法.
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