从青春期早期开始的酒精消费对肺功能和COPD发展的影响 - 一项回顾性队列研究
Mathias Therkelsen King1, Line Bjerrehave Nielsen1, Ulla Møller Weinreich1
1Department of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark.
European clinical respiratory journal
|March 24, 2025
概括
与从未饮酒的人相比,早期饮酒首发 (ACD) 与更高的肺功能 (FEV1,FVC) 有关. 然而,ACD年龄对慢性阻塞性肺病 (COPD) 风险的影响在统计学上并不显著.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 现有研究表明,酒精消费 (AC) 与慢性阻塞性肺病 (COPD) 之间存在U形关联,其中低至中等AC可能具有保护作用.
- 开始饮酒的年龄 (ACD) 对肺功能和COPD发展的具体影响需要进一步研究.
研究的目的:
- 检查开始饮酒的年龄如何影响第一秒内强制呼气体积 (FEV1) 和强制生命能力 (FVC).
- 评估 ACD 的年龄与发展 COPD 的风险之间的关系.
主要方法:
- 一个多中心的队列研究,涉及问卷和精神测量在基线和后续.
- 基于支气管扩展器后的螺旋测量 (FEV1/FVC比率<0.7) 的COPD诊断.
- 统计建模以确定COPD的几率比率 (OR) 和不同ACD年龄组FEV1/FVC的平均差异,调整共变量.
主要成果:
- 与从未喝酒的人相比,有任何AC病史的参与者显示出更高的FEV1和FVC.
- 在FEV1和FVC中最显著的增加是在14-16岁ACD组中观察到的.
- 肺功能差异与晚期ACD减少,在25岁以上和17-18岁ACD组中增幅最小.
- 虽然14-16岁的ACD组对COPD的OR数量较低 (0.83),但其他组的OR数量较高,在21-25岁组 (1.36) 达到顶峰.
结论:
- 与戒酒相比,开始饮酒与肺功能 (FEV1和FVC) 的增强有关,特别是在14-16岁之间开始时.
- 该研究没有发现统计学上有意义的证据,表明酒精消费开始的年龄与患上COPD的风险有关.
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