对药物诱导的肝损伤的洞察:理解和管理策略
Vatsalya Tiwari1, Shrishti Shandily1, Jessielina Albert1
1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India.
Toxicology reports
|March 24, 2025
概括
药物诱导性肝损伤 (DILI) 是一个越来越令人担忧的问题,导致急性肝衰竭和高死亡率. 早期识别和消除致病原体是管理DILI的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
- 内部医学 内部医学
背景情况:
- 药物诱导性肝损伤 (DILI) 是西方国家的重要健康问题,每10万人中发生率为13.9-19.1.
- DILI是急性肝衰竭的主要原因,与高死亡率 (10-50%) 相关.
- 病因包括药物,草药和补充剂,具有风险因素,如先前存在的肝病和营养不足.
研究的目的:
- 审查药物诱导的肝损伤的流行病学,病理生理学,诊断和管理.
- 区分内在和特异性DILI及其致病剂.
- 强调在DILI病例中及时诊断和干预的重要性.
主要方法:
- 关于药物诱导的肝损伤的文献综述.
- 对DILI分类为内在类型和特异类型的分析.
- 讨论诊断方法,包括生物化学测试,血清学标记,成像和肝脏活检.
- 管理策略概要,重点关注戒毒和支持性护理.
主要成果:
- DILI的发病率很大,由于死亡率高,造成了重大威胁.
- 内在的DILI是剂量依赖的 (例如,),而异常的DILI是不可预测的 (例如,NSAID,抗生素).
- 病理生理机制包括氧化应激和线粒体功能障碍.
结论:
- 对DILI的有效管理取决于准确的诊断和迅速撤出违规代理.
- 了解机制和风险因素对于预防和治疗DILI至关重要.
- 基于受伤严重程度和药物类型的量身定制管理对于患者的治疗结果至关重要.
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