血清C1q/瘤坏死因子相关蛋白9的预测和预后值,用于首次缺血性中风
Yan-Qing Zhang1,2, Hai-Feng Zhang3, Xiao-Gang Liu4
1Department of Anesthesiology, University Town Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in neurology
|March 24, 2025
概括
高水平的C1q/瘤坏死因子相关蛋白9 (CTRP9) 可能会保护非超脂血症个体免受缺血性中风的发生. CTRP9似乎也改善了中风患者的存活率,表明其作为预测生物标志物的潜力.
科学领域:
- 生物化学 生物化学
- 心血管科学 心血管科学
- 神经学 神经学
背景情况:
- 与C1q/瘤坏死因子相关的蛋白9 (CTRP9) 是一种阿迪波金,具有证明的大脑血管保护作用.
- 在缺血性中风中CTRP9的临床意义尚未完全阐明.
研究的目的:
- 调查CTRP9作为缺血性中风发病风险预测者的作用.
- 评估CTRP9对缺血性中风患者的预后结果的预后价值.
主要方法:
- 血清CTRP9水平测量了1123名首次缺血性中风患者和835名对照患者在发病后24小时内.
- 对1026名患者进行了生存分析,以评估基线CTRP9对3年全因和心血管死亡率的影响.
- 逐步回归确定了中风发病和死亡率的独立风险因素.
主要成果:
- 在高CTRP9水平 (p <0.05) 的非高脂血症患者中观察到缺血性中风的发病率较低.
- 具有高基线CTRP9的患者在中风后的第一年内表现出明显较低的全因和心血管死亡率 (p <0.05).
- 在缺血性中风患者中,低基线CTRP9被确定为3年全因死亡率的独立风险因素 (p <0.05).
结论:
- 血清CTRP9的升高与非超脂血症个体对缺血性中风发病的保护有关.
- 较高的CTRP9水平至少在中风发作后的一年内保护中风患者的死亡率.
- CTRP9显示出作为缺血性中风的有价值的预测和预后生物标志物的潜力.
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