在Helicobacter pylori感染和肝胆道疾病之间进行分析
Zhenjun Yu1,2, Jie Chen2, Mengdie Chen3
1Department of Gastroenterology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.
Frontiers in cellular and infection microbiology
|March 24, 2025
概括
杆菌 (H. pylori) 感染与胆囊胆固醇晶体和动脉样硬化有关. 这项研究没有发现与脂肪肝,胆结石或胆囊炎的相关性,因此需要进一步研究.
科学领域:
- 胃肠病学 胃肠病学
- 肝胆道医学 肝胆道医学
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (H. pylori) 感染影响了全球近一半的人口.
- 已经确立了H. pylori和外消化疾病之间的联系,但其在胆囊和胆道病理学中的作用仍在争论中.
研究的目的:
- 为了研究H. pylori感染和胆囊/胆道病变之间的关联.
- 为了确定胆固醇晶体和动脉样硬化在H. pylori感染患者的危险因素.
主要方法:
- 对30612名对H. pylori (2018-2022) 进行测试的患者进行了回顾性分析.
- 使用了后勤回归和受限立方线分析.
- 作为外部验证队列,NHANES数据库作为外部验证队列.
主要成果:
- 甲状腺菌感染与白蛋白降低和增加总胆固醇和红细胞沉率有关.
- 在感染患者中增加了胆囊胆固醇晶体 (6.0%对5.1%),胆囊多 (20.2%对19.1%) 和动脉样硬化 (25.6%对21.4%) 的患病率.
- 胆固醇杆菌,年龄,BMI,白蛋白和总胆固醇是胆固醇晶体和动脉样硬化的独立危险因素.
结论:
- 胆囊杆菌感染与胆囊胆固醇晶体和动脉样硬化显著相关.
- 在H. pylori感染和脂肪肝,胆结石或胆囊炎之间没有发现显著的关联.
- 建议进行多中心,前性研究以进一步验证.
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