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循环无细胞线粒体DNA与突然的感觉神经听力损失的关联

Chao-Hui Yang^1,2,3,4, Ming-Yu Yang^1,5, Wei-Che Lin⁶

¹Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|March 24, 2025

概括

突发感神经听力损失 (SSNHL) 患者中细胞自由线粒体DNA (ccf-mtDNA) 水平升高与类固醇治疗后更好的结果相关. 这表明ccf-mtDNA可以预测SSNHL患者的治疗成功.

科学领域:

生物化学生物化学
遗传学是一个遗传学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

突发感神经听力损失 (SSNHL) 是一种复杂的疾病,治疗反应各不相同.
确定可靠的生物标志物来预测SSNHL结果对于有效的患者管理至关重要.

研究的目的:

研究循环无细胞线粒体DNA (ccf-mtDNA) 水平与SSNHL的严重程度和治疗结果之间的关联.
确定ccf-mtDNA是否可以作为SSNHL恢复的预测生物标志物.

主要方法:

在一个高等学术医学中心进行了一项观察前性研究.
在接受类固醇治疗之前,从50名SSNHL患者和30名健康对照人群收集了血样本.
量化聚合酶链反应 (qPCR) 用于测量ccf-mtDNA水平;通过听力增益和恢复百分比来评估治疗结果.

主要成果:

与健康对照组相比,SSNHL患者的血ccf-mtDNA水平显著更高.
在良好的康复患者和康复不良患者中观察到较高的治疗前ccf-mtDNA水平.
ccf-mtDNA水平与听力增长和恢复百分比有积极的相关性,并且是良好的恢复的独立预测指标.

结论:

血ccf-mtDNA水平升高与SSNHL相关.
ccf-mtDNA水平与接受类固醇治疗的SSNHL患者更好的治疗结果有显著联系.
ccf-mtDNA显示出作为SSNHL治疗成功的预测生物标志物的潜力,有助于个性化治疗策略.

关键词:

在循环的无细胞线粒体DNA中.突然的感觉神经神经听力损失.治疗的结果.

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相关概念视频

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

Hair Cells

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.