一种通用和多功能Zwitterionic涂层用于长长和复杂几何形状的血液接触导管
Tong Zhang1,2,3, Tian Liang1,2,3, Qichao Pan1,2,3
1School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Baoshan, Shanghai, 200444, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 24, 2025
概括
一种新的zwiwterion涂层为医疗器械提供了卓越的抗凝和近零污染. 这种通用,经济高效的方法还可以实现选择性生物捕获,提高血液接触导管的安全性和功能.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 医疗设备工程 医疗设备工程
背景情况:
- 接触血液的导管面临血栓形成的风险,需要氨酸涂层.
- 氨酸涂层存在局限性,这促使人们寻找先进的替代品.
- 开发坚固,耐腐蚀的涂层对于医疗器械安全至关重要.
研究的目的:
- 为医疗器械开发一种经济高效,机械可行和通用的zwitterion涂层.
- 为了实现接近零的污染,超级抗凝,和选择性的生物捕获能力.
- 为了证明涂层对各种导管类型和尺寸的适应性.
主要方法:
- 使用湿的启动轴承聚合物,用于在水性环境中快速地表组装.
- 将超性和性聚合物植入导管内壁上.
- 在十种不同的基板和复杂的导管几何形状上测试了涂层适应性.
主要成果:
- 在广泛的pH范围内实现了接近零的蛋白质污染.
- 对血液细胞和细菌表现出优越的抵抗力.
- 在模拟的血液循环条件下证实了出色的稳定性,同时保持了抗凝剂性能.
- 成功使血液中的循环瘤细胞能够被选择性地捕获.
结论:
- 采用zwitterion涂层技术为医疗器械提供了一种多功能且有效的解决方案.
- 提供快速修改,强大的抗凝固和可定制的生物功能.
- 为具有挑战性的生物环境提供了对肝素涂层的有吸引力的替代品.
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