Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
Two...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The cloacal outgrowth orchestrates co-development of the bladder and umbilical arteries.

Development (Cambridge, England)·2026
Same author

Author Correction: ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.

Nature communications·2026
Same author

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis.

Nature communications·2025
Same author

The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis.

Nature communications·2025
Same author

Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression.

Nature communications·2024
Same author

Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction.

The EMBO journal·2024

相关实验视频

Updated: May 11, 2026

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.1K

RACK7与PRC2复合体相互作用,以调节星细胞发育.

Fangfang Jiao1,2, Tianxiang Tang3, Bowen Wang4

  • 1Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 24, 2025
PubMed
概括

活性C-激酶7 (RACK7) 的受体对正常的大脑发育至关重要. 在小鼠中,RACK7的丧失会通过扰乱天体细胞发育和基因调节,导致发育缺陷.

关键词:
星球细胞的发展.H3K27me3 在线阅读PRC2 复合体是一个复合体.在RACK7中,RACK7是第七个.没有信号通路.在 ZMYND8 里,你会看到 ZMYND8 .

更多相关视频

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators
12:19

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Published on: November 19, 2014

14.8K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

相关实验视频

Last Updated: May 11, 2026

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.1K
Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators
12:19

Imaging Intracellular Ca2+ Signals in Striatal Astrocytes from Adult Mice Using Genetically-encoded Calcium Indicators

Published on: November 19, 2014

14.8K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

科学领域:

  • 神经科学是一个神经科学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 发展生物学 发展生物学

背景情况:

  • 表观遗传机制对于大脑发育和疾病至关重要.
  • 活性C-激酶7 (RACK7) 的受体,一种表观遗传阅读器,与神经发育有关,但体内数据有限.

研究的目的:

  • 为了研究RACK7在脑发育中的体内作用.
  • 阐明RACK7调节天体细胞发育和神经功能的分子机制.

主要方法:

  • 为Rack7.7建立了一个有条件的淘汰鼠标模型.
  • 利用分子生物学技术来研究RACK7与表观遗传修饰物的相互作用.
  • 在Rack7缺陷的星体细胞中分析了基因表达和染色质定位.

主要成果:

  • 缺乏Rack7的小鼠表现出显著的发育缺陷和异常的天体细胞发育.
  • 发现RACK7与多抑制复合体2 (PRC2) 相互作用,以调节H3K27甲基化.
  • 删除Rack7导致H3K27me3染色体局部减少和失调的Wnt信号通路.
  • RACK7和H3K27me3合作控制天体细胞分化基因.

结论:

  • RACK7在调节星球细胞发育和大脑形成方面发挥着至关重要的作用.
  • 这项研究揭示了一种涉及神经发育中的RACK7,PRC2和H3K27甲基化的新机制.
  • 这些发现为神经发育障碍的分子基础提供了新的见解.