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复杂的炎症和营养指数预测急性冠状动脉综合征患者进行皮肤冠状动脉干预的预后风险

Ge Song¹, Xinchen Wang¹, Chen Wei¹

¹Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, China.

Immunity, inflammation and disease

|March 24, 2025

概括

系统性炎症反应指数 (SIRI),结合HDL-C和LDL-C水平,可以预测PCI后急性冠状动脉综合征 (ACS) 患者的主要不良心血管事件 (MACE). 较高的SIRI值表明MACE风险增加,提供预后见解.

科学领域:

心脏病学心脏病学
生物标志物生物标志物
炎症炎症是一种炎症.

背景情况:

急性冠状动脉综合征 (ACS) 构成显著的心血管风险.
穿皮冠状动脉干预 (PCI) 是ACS的常见治疗方法.
在接受PCI的ACS患者中,主要心血管不良事件 (MACE) 的预测标记对于风险分层至关重要.

研究的目的:

评估系统性炎症反应指数 (SIRI) 与高密度脂蛋白胆固醇 (HDL-C) 和低密度脂蛋白胆固醇 (LDL-C) 水平相关的预后值.
确定SIRI,SIRI/HDL-C比率和SIRI×LDL-C产品与PCI接受ACS患者的MACE的关联.

主要方法:

分析了1377名在2016年1月至2018年12月期间接受PCI的ACS患者队列.
患者被分为MACEs (n=60) 和非MACEs (n=1317) 组.
统计分析包括卡普兰-梅尔曲线,考克斯比例危险模型和受限立方线模型.

主要成果:

在MACEs和非MACEs组之间观察到年龄,心力衰竭史,心肌梗塞,心脏性休克,左心室喷射率和特定SIRI相关指数 (SIRI ≥2.848,SIRI/HDL-C ≥1.977,SIRI×LDL-C ≥4.609) 的显著差异.
较高的SIRI水平与较低的累积存活率有关.
在接受PCI的ACS患者中,SIRI ≥2.848,SIRI/HDL-C ≥1.977和SIRI×LDL-C ≥4.609被确定为MACE的独立风险因素.

结论:

升高的SIRI水平,特别是与特定的HDL-C和LDL-C值相结合时,在接受PCI的ACS患者中作为独立的预后风险因素.
这些基于SIRI的指数可以为评估这种患者群体的长期预后提供有价值的工具.

关键词:

急性冠状动脉综合征急性冠状动脉综合征通过皮肤进行冠状动脉干预.预后预后预后系统性炎症反应指数

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