使用气凝和超临界流体技术设计具有改善生物活性和生物可用性的黄素颗粒
Farhad Alavi1, Kaustav Majumder1, Ozan N Ciftci1,2
1Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-6205, United States.
ACS applied materials & interfaces
|March 24, 2025
概括
这项研究使用粉气凝和超临界CO2开发了低结晶度的黄素颗粒,以增强黄素.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物化学 生化学
背景情况:
- 黄素 (CUR) 已知有健康益处,但由于其高结晶度和水溶性差,其生物利用性有限.
- 降低黄素结晶性的方法对于释放其全部治疗潜力至关重要.
- 纳米孔状材料提供了一种有前途的方法来改善不溶性化合物的物理性质和生物可用性.
研究的目的:
- 使用纳米孔隙粉气凝和超临界二氧化碳 (SC-CO2) 开发低晶度的黄素颗粒.
- 为了提高黄素的生物可用性和抗氧化活性.
- 为了确定SC-CO2辅助的黄素浸到粉气凝中的最佳条件.
主要方法:
- 在使用超临界CO2的情况下,黄入纳米多孔粉气凝.
- 使用各种技术对黄素结晶性和分布进行表征.
- 在水性介质中评估抗氧化剂活性.
- 在体外胃肠道消化和Caco-2细胞运输研究以评估生物可访问性和生物可用性.
主要成果:
- SC-CO2方法有效降低了黄素的结晶性,而更高的浸温度导致了更低的结晶性和更好的分布.
- 黄素浸的气凝显示出显著增强的抗氧化活性.
- 在体外研究显示,与原生黄相比,黄在120°C浸的生物可访问性约为30倍.
- 在120°C以1:9的黄素与气凝比率进行浸,可获得结晶性和生物可用性的最佳结果,可测量的Caco-2细胞传输.
结论:
- 在粉气凝中SC-CO2辅助浸是一种新且有效的方法,用于生产低晶度的黄素颗粒.
- 这种方法显著提高了黄素的抗氧化活性,以及体外生物可访问性和生物可用性.
- 由此产生的黄浸食用粉气凝适合作为促进健康产品的功能性食品成分使用.
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