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Updated: May 20, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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通过使用碳化作为基因来源的 dearomatization 构建螺旋碳环基架

Zhiqiang Wang1, Botao Wang1, Jiao Wang1

  • 1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, P. R. China. lizheng@nwnu.edu.cn.

Organic & biomolecular chemistry
|March 24, 2025
PubMed
概括

这项研究引入了一种新的一步方法,用于使用碳化制造复杂的螺旋碳循环支架. 这种方法为合成有价值的有机化合物提供了传统的乙基反应的高效和更安全的替代方案.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
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