用后生菌增强口服补水溶液缓解虚弱老年人腹相关炎症:来自随机,双盲,安慰剂控制研究的见解
Julian Andrés Mateus Rodríguez1,2, Patricia Rodríguez Sanz1, Edgar Kostandyan2
1Hospital d'Atenció Intermedia Colisée Barcelona Isabel Roig, 08030 Barcelona, Spain.
一种新的口服补水溶液 (ORS),富含后生物ABB C22®,可显著降低腹的老年人炎症标志物. 这种后生物增强的ORS为控制腹和相关肠道炎症提供了有希望的方法.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 老年病的医生 老年病的医生
背景情况:
- 老年人的腹会导致脱水,营养不良和生活质量下降.
- 在腹发作期间持续的炎症可能导致并发症和复发.
- 需要新的治疗策略来管理老年人腹相关的炎症.
研究的目的:
- 为了评估口服补水溶液 (ORS) 强化后生物ABB C22®在经历腹的老年人中的抗炎作用.
- 评估ABB C22®对关键炎症生物标志物和便一致性的影响.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及47名65岁及以上的腹患者.
- 参与者接受了ABB C22®丰富的ORS或安慰剂ORS,长达14天.
- 主要终点包括便calprotectin,乳酸铁素和血清免疫球蛋白A的变化;次要终点评估了便的一致性.
主要成果:
- 与安慰剂组相比,接受ABB C22®的ORS组在第14天显示出便中calprotectin和lactoferrin水平的显著降低.
- 在ABB C22®干预组中,乳酸铁素阳性病例在第三天减少了50%.
- 两组都显示出便一致性的改善,没有报告的不良事件.
结论:
- 与标准的ORS相比,ABB C22®丰富的ORS在腹的老年人中表现出优异的抗炎性质.
- 后生物质强化配方为治疗腹提供了一个有希望的治疗途径,特别是在伴随着肠道炎症时.
- 这种方法可以通过针对炎症与补水一起改善患者的治疗结果.
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