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Updated: May 20, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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大规模的定量交叉连接和质谱学为器官,细胞和组织中的蛋白质形态可塑性提供了新的洞察力

Andrew Keller1, Anna Bakhtina1, James E Bruce1

  • 1Department of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.

Journal of proteome research
|March 24, 2025
PubMed
概括

本研究介绍了一种方法,以使用定量交叉链接数据,根据蛋白质交叉链接的构造状态分组蛋白质交叉链接. 这种方法有助于理解蛋白质动力学和细胞中的结构变异.

关键词:
化学交叉连接 化学交叉连接交叉链接的数据库数据库.质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量蛋白质复合体 蛋白质复合体蛋白质结构 蛋白质结构量化XL-MS的使用情况.

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Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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