与药物相关的下巴骨髓缩的预后指标:系统性审查和元分析
Ling-Ying Wei1,2, Ching-Ming Chiu3,4, Sang-Heng Kok1,5
1Department of Dentistry, School of Dentistry, College of Medicine, National Taiwan University, No. 1, Chang-De Street, Taipei, 10048, Taiwan.
概括
停止抗吸收疗法和手术治疗改善了与药物相关的下巴骨硬化 (MRONJ) 的结果. 恶性病变和晚期病变阶段与MRONJ患者的愈合状况较差有关.
科学领域:
- 口腔和牙面部外科手术
- 在瘤学瘤学.
- 药理学 药理学 是一个学科.
背景情况:
- 抗吸收剂可以损害骨愈合,导致与药物相关的骨缩 (MRONJ).
- 虽然研究了MRONJ的流行和预防,但治疗结果和预后因素需要进一步调查.
研究的目的:
- 系统地审查和分析影响治疗结果的预后因素,在与药物相关的骨硬化患者.
主要方法:
- 一项对1388个选引用的系统审查,其中包括33项符合纳入标准的研究.
- 预后因素被分为与药物相关的,潜在的疾病,与病变相关的,血清标志物和治疗方式.
主要成果:
- 停止抗吸收疗法和手术治疗与更好的MRONJ结局有关.
- 恶性 (特别是多发性骨髓瘤) 和晚期的病变阶段与更糟糕的结果相关.
- 大病变和形形成显示出更好的愈合,而周骨反应显示出更差的结果.
结论:
- 确定了MRONJ的预后指标,可以帮助临床决策和患者讨论.
- 这些发现支持在患有MRONJ病变的患者中考虑推迟抗吸收疗法.
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