多种疾病,参与活动和认知功能之间的纵向关联:交叉延迟调解分析
Shuojia Wang1,2,3, Zikuan Yang4, Yilin Chen1
1Department of Geriatrics, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, China.
概括
多种疾病和认知功能在老年人中具有双向联系,身体和休活动作为关键调解者. 在没有APOE ε4基因变异的个体中没有观察到这种关联.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明多病症和认知功能之间存在联系,但方向和机制尚未完全理解.
- 老年人特别容易受到多种慢性疾病和认知衰退之间的相互作用的影响.
研究的目的:
- 研究老年人多病症和认知功能之间的双向关系.
- 检查体育活动和休活动在这个协会中的调解作用.
主要方法:
- 利用了来自健康和退休研究 (2008-2016) 的5546名60岁以上的无痴呆症美国人的数据.
- 使用多病症重量指数评估多病症和通过认知状态的电话访谈认知功能.
- 采用交叉差距的小组模型来分析协会和调解效应.
主要成果:
- 在多病症和认知功能之间发现了显著的双向关联.
- 高多发病率预测了较低的认知功能 (β = -0.064),而较低的认知功能预测了较高的多发病率 (β = -0.024).
- 身体和休活动显著调解了这些关联,这种影响从多病症到认知功能更为明显.
结论:
- 在老年人中,多病症和认知功能之间存在负面的双向关联.
- 身体和休活动在调解这种关系方面发挥着至关重要的作用.
- 双向关联只在那些不是APOE ε4基因变异的携带者的人群中显而易见.
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