高血压和心房动:来自AF-SCREEN国际合作的前沿研究
Teemu J Niiranen1,2,3, Renate B Schnabel4,5, Aletta E Schutte6,7
1Department of Internal Medicine, University of Turku, Turku, Finland (T.J.N.).
Circulation
|March 24, 2025
概括
高血压显著增加了心房动 (AF) 的风险. 同时查和治疗高血压可以预防AF和相关心血管问题,尽管需要更多的研究.
科学领域:
- 心脏病学
- 高血压研究
- 对心房的研究
背景情况:
- 高血压是心房的主要可改变的风险因素,影响了70%以上的心房患者.
- 由于高血压和肌肉功能往往未被诊断和治疗,因此大大增加了中风,心力衰竭,痴呆和死亡的风险.
研究的目的:
- 审查高血压,心肌梗塞和心血管结果之间的联系的证据.
- 探索同时进行高血压和AF查.
- 通过抗高血压治疗来评估AF的预防.
主要方法:
- 由AF-SCREEN国际协作的29名成员进行专家审查.
- 综合现有证据和识别知识缺口.
- 分析用于同时检测高血压和AF的自动血压装置.
主要成果:
- 高血压和肌肉动脉紧密相关,它们的综合作用增加了主要心血管事件和死亡风险.
- 自动化血压装置显示可能同时进行高血压和AF查,需要对AF进行心电图确认.
- 抗高血压疗法有效降低AF风险,特别是在左心室功能障碍的患者中.
结论:
- 高血压应该是AF预测和预防的主要目标,而不仅仅是伴随性疾病.
- 高危人群 (≥65岁,耐治疗高血压) 可能受益于AF查.
- 需要进一步研究最佳查方法,患者选择,抗高血压药物类别以及预防AF的血压目标.
相关概念视频
01:33Hormonal Regulation
32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
354
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
354
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
517
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
517
01:18Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
560
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
560
01:28Factors affecting Blood pressure
2.8K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
2.8K