在脊髓损伤患者中完全植入脑电脑接口的5年随访
Kevin C Davis1,2, Kimberley R Wyse-Sookoo3, Fouzia Raza4
1Department of Biomedical Engineering, University of Miami, Miami, FL 33146, United States of America.
Journal of neural engineering
|March 24, 2025
概括
使用心电图 (ECoG) 完全植入的脑电脑接口证明了长期稳定性和脊髓损伤 (SCI) 患者的家庭使用. 这项技术有望改善社区环境中的生活质量和独立性.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 康复技术 康复技术 康复技术
背景情况:
- 脊髓损伤 (SCI) 影响了美国超过25万个人,脑电脑接口 (BCI) 提供了改善生活质量的潜力.
- 现有的侵袭性皮层内BCI面临着慢性退化和硬件绑定方面的挑战.
- 基于电皮质谱 (ECoG) 的BCI研究较少,特别是家庭使用的完全植入的系统.
研究的目的:
- 评估完全植入基于ECoG的BCI系统的长期可行性和可行性,用于SCI患者的家庭使用.
- 评估ECoG录音的稳定性,信号质量和解码器性能在现实环境中长期使用.
主要方法:
- 一名患有SCI的患者使用了长期,完全植入的基于ECoG的BCI系统来控制实验室和家庭环境中的骨架.
- 通过测量电极接触阻抗,信号噪声比,信号带宽和解码器性能 (AUROC) 来评估长期可行性.
- 数据收集时间超过54个月,其中很大一部分来自患者的家庭和社区环境.
主要成果:
- 在54个月的时间里,ECoG-BCI系统在家中每天平均使用38±24分钟.
- 六个月后观察到稳定的事件相关脱同步,有助于运动意图检测.
- 解码器实现了0.959的接收器操作员特征曲线 (AUROC) 下的平均区域,证明了可靠的机动图像分类和控制.
结论:
- 本研究介绍了一个完全植入的基于ECoG的BCI的长期可行性和可行性,用于SCI患者的家庭和社区使用.
- 这些发现表明,稳定的ECoG记录适用于长时间的电机控制应用.
- 需要更多的参与者和电极进行进一步的研究,以确认这些有前途的趋势,以获得更广泛的临床实用性.
更多相关视频
09:42Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
Published on: September 1, 2023
1.1K
06:11Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients
Published on: April 18, 2025
194
相关概念视频
The Spinal Cord
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
Spinal Cord: Information Processing
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Spinal Cord
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
Traumatic Brain Injury l: Introduction
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
