骨盆器官脱落和更年期激素治疗之间的关系:全国性队列研究
Hee-Yeong Jung1, Tae-Ran Kim1, Gwan Hee Han1
1Department of Obstetrics and Gynecology, Inje University Sanggye Paik Hospital, School of Medicine, Inje University, Seoul, Korea.
Obstetrics & gynecology science
|March 24, 2025
概括
使用Tibolone或联合雌激素加孕激素 (CEPM) 进行更年期激素治疗 (MHT) 可能会降低盆腔器官脱落 (POP) 的风险. 其他MHT类型在绝经后妇女中没有与POP风险显著相关.
科学领域:
- 妇科 妇科 妇科 妇科
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 骨盆器官脱落 (POP) 是一种常见的疾病,影响绝经后妇女.
- 更年期激素治疗 (MHT) 用于管理更年期症状,但其对POP的影响尚未完全理解.
研究的目的:
- 调查不同类型的更年期激素治疗 (MHT) 与更年期后妇女的骨盆器官脱落 (POP) 风险之间的关联.
主要方法:
- 一项回顾性队列研究,利用韩国国家卫生检查和保险数据从2002年到2019年.
- 纳入标准包括绝经后的妇女,MHT组 (使用MHT>6个月) 和非MHT组.
- 统计分析包括调整的危险比率 (aHR) 和99%的置信区间 (CI).
主要成果:
- 蒂博隆 (aHR,0.87) 和由制造商 (CEPM) 提供的联合雌激素加孕激素 (aHR,0.821) 与减少POP风险有关.
- 其他口服MHT和透皮雌激素与非MHT组相比,POP风险没有显著差异.
- 较低的BMI (<18.5) 与降低的POP风险有关,而较高的BMI (23-29.9) 增加了风险. 增加的平价也与更高的POP风险有关.
结论:
- 提博和CEPM的使用与绝经后妇女的骨盆器官脱落风险降低有关.
- 其他MHT类型与POP风险之间没有发现显著的关联.
- 身体质量指数和平价是影响POP风险的重要因素.
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