在癌症预防研究中的成年人中,非营养甜味剂消费,代谢风险因素和炎症生物标志物-3饮食评估子研究
Allison C Sylvetsky1, Ying Wang2, Ananya G Reddy2
1Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States.
The Journal of nutrition
|March 24, 2025
概括
非营养甜味剂 (NNSs) 与大多数代谢风险因素无关. 然而,在超重或肥胖的成年人中,NNS消费与中白素-6 (IL-6) 有积极的关联.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 炎症研究 炎症研究
背景情况:
- 非营养甜味剂 (NNSs) 是常见的糖替代品,但它们对健康的影响仍在争论中.
- 了解NNS对代谢健康和慢性疾病的影响至关重要.
研究的目的:
- 调查NNS消费与代谢风险因素之间的关联.
- 检查NNS摄入量和炎症生物标志物之间的联系.
主要方法:
- 从癌症预防研究-3饮食评估子研究中对624名成人的横截面分析.
- 通过饮食回忆来测量NNS消耗,并评估禁食胰岛素,C-,HbA1c,瘦素,阿迪波内克丁,CRP,TNF-α,IL-6和IL-10.
- 使用多变量线性回归,调整人口统计,BMI,饮食质量和能量摄入.
主要成果:
- 消费NNS与瘦素和CRP有积极的关联,但在调整后,这些减弱了.
- 对于胰岛素,C-,HbA1c,阿迪波内克丁,TNF-α或IL-10没有发现显著的关联.
- 在BMI≥25kg/m2的参与者中观察到NNS消费和IL-6之间的积极关联.
结论:
- 在调整后,NNS消费和代谢/炎症标志物之间的总体关联是零的.
- 消费NNS与超重或肥胖个体的IL-6增加有关.
- 需要进一步研究NNS对炎症通路的影响机制.
关键词:
人工甜味剂是一种人工甜味剂.癌症 癌症 癌症 癌症 癌症心脏代谢疾病心脏代谢疾病心血管疾病心血管疾病糖尿病 糖尿病患者 糖尿病患者这是一种饮食苏打水.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖糖 糖 糖 糖 糖 糖 糖 糖更多相关视频
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