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Updated: Jul 8, 2026

Use of Recombinant Fusion Proteins in a Fluorescent Protease Assay Platform and Their In-gel Renaturation
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一种新型蛋白质降解剂FPFT-221616的设计,合成和评估

Yasuyuki Ueda1, Takashi Ando1, Yoshiteru Eikyu1

  • 1Department of Scientific Research, Fujimoto Pharmaceutical Corporation, 1-3-40, Nishiotsuka, Matsubara, Osaka 580-8503, Japan.

Bioorganic & medicinal chemistry letters
|March 24, 2025
PubMed
概括

研究人员开发了FPFT-2216,一种具有独特化学结构的多发性骨髓瘤 (MM) 新型候选药物. 与现有治疗方法相比,这种新化合物表现出优越的抗瘤活性,以及与达拉图穆马布的协同效应.

关键词:
头脑黄金是什么意思IKAROS家族的指1分子粘合剂是一种分子粘合剂.多发性骨髓瘤是一种多发性骨髓瘤.蛋白质降解剂可以降解蛋白质.

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...