相关实验视频
Updated: Jul 1, 2026
09:00
Olfactory Behavioral Testing in the Adult Mouse
Published on: January 28, 2009
19.4K
AROMHA大脑健康测试是一种远程嗅觉评估,用于选认知障碍
Benoît Jobin1,2, Colin Magdamo1,3, Daniela Delphus1
1Department of Neurology, Massachusetts General Hospital, Boston, MA, 02129, USA.
Scientific reports
|March 25, 2025
概括
一个新的数字测试在家中评估嗅觉,以检测认知能力下降的早期迹象. 这种非侵入性方法对识别患有阿尔茨海默病和其他神经认知障碍的风险个体有希望.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 诊断医学 诊断医学 诊断医学
背景情况:
- 需要对阿尔茨海默病 (AD) 等临床前神经认知障碍进行具有成本效益的非侵入性查.
- 嗅觉回路显示在AD临床症状之前的病理变化.
- 早期检测可以促进及时干预和管理.
研究的目的:
- 开发和验证数字远程AROMHA大脑健康测试 (ABHT),用于在家进行嗅觉评估.
- 评估ABHT在不同人群中检测认知障碍的能力.
- 为了评估不同管理方法和语言群体的嗅觉功能.
主要方法:
- 评估气味识别,歧视,记忆和强度的ABHT是远程和亲自进行的.
- 参与者包括认知正常 (CN),主观认知投诉 (SCC) 和轻度认知障碍 (MCI) 个体.
- 测试是在观察和未观察的远程环境中进行的,以及亲自进行的.
主要成果:
- 嗅觉表现在远程观察/未观察和英语/西班牙语管理中是一致的.
- 气味记忆,识别和歧视随着年龄的增长而下降.
- 不管年龄,性别或教育程度,MCI参与者的嗅觉识别和歧视程度低于CN和SCC组.
结论:
- 该ABHT有效地识别与年龄相关的嗅觉衰退,并区分认知障碍的个体.
- 远程,自我管理的嗅觉测试显示了可行性和可靠性.
- 该ABHT具有早期识别和监测患痴呆风险的个人的潜力.
相关概念视频
01:25Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
01:03Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
01:20Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...