通过导管动脉栓塞作为治疗骨关节炎导致的慢性疼痛的方法
Florian Nima Fleckenstein1,2,3, Jan Voss4,5, Christian Doll5
1Department of Diagnostic and Interventional Radiology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. florian.fleckenstein@charite.de.
Cardiovascular and interventional radiology
|March 25, 2025
概括
超动脉栓塞 (TAE) 提供了一种安全的,最小的侵入性治疗关节骨关节炎 (TMJ-OA) 症状耐受常规疗法. 这项研究显示了TMJ-OA患者减轻症状的有希望的结果.
科学领域:
- 干预性放射学 干预性放射学
- 口腔和牙面部外科手术
- 类风湿病学 类风湿病学
背景情况:
- 关节骨关节炎 (TMJ-OA) 在疼痛管理和功能恢复方面提出了重大挑战.
- 对于TMJ-OA的传统治疗方法,对于耐火病例来说,往往会产生低于最佳的结果.
研究的目的:
- 评估通过动脉栓塞 (TAE) 缓解TMJ-OA相关症状的疗效和安全性.
- 探索TAE作为对标准治疗无反应的TMJ-OA患者的最小侵入性治疗选择.
主要方法:
- 在三个患有TMJ-OA的女性患者身上进行了六次超选择性TAE手术,这些女性患者之前的保守和手术干预都失败了.
- 使用Imipenem/Cilastatin与对比剂混合的CBCT成像引导的微导管放置用于栓塞.
- 使用口腔健康影响概况-关节 (OHIP-TMD) 和数值评分表 (NRS) 对基线和随访间隔 (4周,3个月和6个月) 的疼痛进行了评估.
主要成果:
- 在所有六个程序中,TAE在没有报告任何不良事件的情况下取得了技术上的成功.
- 在OHIP-TMD得分中观察到显著改善,在患者之间下降.
- 数值评分尺度 (NRS) 疼痛评分在TAE治疗后显示出显著的改善.
结论:
- 跨动脉栓塞 (TAE) 为选择的TMJ-OA患者提供了一种可行且安全的最小侵入性治疗方式.
- 建议对更大的患者队列和延长后续期进行进一步的研究,以验证这些初步发现.
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