HPV亚型感染与怀孕结果的分布和关系
Yingying Lin1, Zhiwei Chen2, Xinye Zheng2
1Department of Healthcare, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Scientific reports
|March 25, 2025
概括
在怀孕期间感染人类乳头瘤病毒 (HPV) 是很常见的,影响近20%的妇女. 特定的HPV类型增加了早产,剖腹产和高血压疾病的风险,影响了母亲和婴儿的健康.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 感染在怀孕期间存在风险,但关于疫苗覆盖和未覆盖的高风险亚型及其对母亲和儿童健康的影响的数据有限.
- 了解HPV患病率及其与怀孕结果的关联对于公共卫生倡议至关重要.
研究的目的:
- 在怀孕期间调查九价值疫苗覆盖和未覆盖的高风险HPV亚型的感染率.
- 分析特定HPV感染与母亲和新生儿不良结果之间的关联.
主要方法:
- 一项追溯的队列研究,包括7110名接受HPV检测的孕妇.
- 用多个逻辑回归分析来确定HPV感染和结果之间的关联.
主要成果:
- 总体HPV感染率为19.9%,其中HPV类型52,16,58,42和51是最常见的.
- 九价疫苗覆盖的HPV感染增加了早产早期膜破裂 (PPROM) 和剖腹产的风险.
- 与疫苗覆盖的和未覆盖的HPV亚型的同时感染增加了剖腹产,妊娠高血压障碍,妊娠年龄 (SGA) 婴儿小的风险,以及新生儿ICU入院的风险.
结论:
- 怀孕期间的特定HPV感染与母亲和新生儿的不良结果有显著的相关性.
- 建议提高HPV疫苗接种率和开发非九价性HPV疫苗,以改善孕产妇和胎儿的健康.
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