大脑结构-功能合变化的模式与身高和生长激素相关的变化在身高矮的儿童中
Yi Lu1,2,3, Xiaojun Chen1, Jing Tang4
1Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Pediatric research
|March 25, 2025
概括
青少年的矮身,与生长激素 (GH) 水平相关,影响大脑连接. 感官区域结构-功能合的减少表明对发育变化的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 内分泌学 在内分泌学.
背景情况:
- 青少年身高差异与不同的生长激素 (GH) 水平有关.
- 生长激素缺乏症 (GHD) 和异常矮身 (ISS) 呈现出不同的临床特征.
- 了解与内分泌功能相关的大脑发育至关重要.
研究的目的:
- 调查身高,GH水平和大脑结构-功能连接 (SC-FC) 合之间的关联.
- 为了比较青少年的SC-FC合模式与GHD,ISS和健康对照 (HC).
- 为了探索GH对神经网络在矮个体的影响.
主要方法:
- 对79名GHD,88名ISS和37名HC受试者的回顾性分析.
- 使用多式脑MRI (DTI和rs-fMRI) 来获得SC-FC合矩阵.
- 采用ANOVA,Tukey HSD测试,以及小组和相关性分析的部分相关性.
主要成果:
- 与HC相比,矮身群 (GHD,ISS) 在初级感官区域 (视觉,感官运动) 中的SC-FC合减少.
- 感应运动网络在所有组中表现出最高的网络内部变化.
- GHD显示了比ISS更大的网络间SC-FC合变异性;HC的变异性最小.
结论:
- 身高和GH水平显然影响了矮身儿童的大脑结构-功能合.
- 主要感官大脑区域容易受到影响GH水平的发育变异的影响.
- GH在调节大脑连接方面发挥着关键作用,特别是在GHD中,影响认知和行为结果.
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