新生儿死性肠球炎的临床特征,有或没有先天性心脏病:一个病例对照研究
Kaiyishaer Balati1, Zhuoming Xu2, Limin Zhu2
1Department of Neonatology, Second People's Hospital of Kashi Prefecture, Kashi, 844099, Xinjiang Province, China.
Italian journal of pediatrics
|March 25, 2025
概括
与先天性心脏病 (CHD) 相关的死性肠球炎 (NEC) 主要影响到满期婴儿,与影响早产婴儿的非CHD NEC不同. 这两个群体的临床特征显著不同,这表明了不同的病理生理机制.
科学领域:
- 新生儿科学 新生儿科学
- 儿童心脏病学 儿童心脏病学
- 胃肠病学 胃肠病学
背景情况:
- 死性肠球炎 (NEC) 是新生儿的一种严重疾病.
- 先天性心脏病 (CHD) 是NEC的已知风险因素.
- 了解与CHD相关的NEC和非CHD相关的NEC之间的差异对于有针对性的治疗至关重要.
研究的目的:
- 分析和比较新生儿与CHD相关的NEC和与非CHD相关的NEC的临床特征.
- 为了确定两个群体之间的独特特征和潜在的病理生理差异.
主要方法:
- 在2014年至2023年期间,对符合贝尔的NEC分期标准的住院患者进行了回顾性研究.
- 包括一个与CHD相关的NEC组 (CHD-NEC) 和一个与非CHD相关的NEC的匹配对照组 (nCHD-NEC).
- 记录和比较基本信息,NEC前临床事件,NEC严重程度和治疗.
主要成果:
- 而CHD-NEC组 (60例) 与nCHD-NEC组 (120例) 有显著差异.
- CHD-NEC与更长的妊娠年龄,更重的出生体重,更高的直通道动脉发生率,休克和机械通风有关.
- nCHD-NEC显示出更高的妊娠年龄小的发病率,膜的过早破裂,以及早期/晚期发病的败血症.
结论:
- 患有CHD-NEC和nCHD-NEC的新生儿表现出不同的临床特征.
- 长期婴儿中CHD-NEC似乎与外科手术期间的肠道缺血有关,而nCHD-NEC与早产,不成熟的肠道和感染有关.
- 需要进一步的前性研究来阐明NEC的病原体和优化管理.
相关概念视频
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...


