在后COVID-19时代设计新的"嗅助剂"以改善嗅觉功能
Veronica L Formanek1, Barak M Spector1, Gabriela Zappitelli1
1Department of Otolaryngology - Head & Neck Surgery, The Ohio State University, Columbus, OH, 43212, USA.
BMC medicine
|March 25, 2025
概括
新的"嗅助剂"增强了鼻内气味的传递,改善了健康个体和嗅觉损失患者的嗅觉功能,包括COVID后的嗅觉缺陷. 这些设备为嗅觉障碍提供了潜在的非处方药解决方案.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 感官替代技术存在于视觉和听觉,但不是嗅觉.
- 嗅觉功能障碍是一个重大问题,特别是在COVID-19后的时代.
- 需要技术解决方案来增强或恢复嗅觉.
研究的目的:
- 开发和评估称为"气味助剂"的非侵入性设备,以增强鼻内气味的传递.
- 研究这些原型在改善健康受试者和嗅觉损失患者的嗅觉功能的有效性.
主要方法:
- 开发了两个原型:一个带有通道的鼻泡塞和一个鼻.
- 在58名健康受试者身上测试了原型,以评估气味检测值.
- 在54名患有嗅觉损失的患者身上评估了原型,包括COVID-19后的病例,使用NIH工具箱气味识别得分.
主要成果:
- 这两种原型都改善了正常嗅觉功能的健康人群的气味检测值.
- 嗅觉辅助器显著改善了患有嗅觉损失的患者的气味识别得分.
- 鼻塞在COVID-19后的嗅觉损失方面是有效的,而剪贴在低气/无气症方面是有效的.
结论:
- 开发的"嗅助剂"在通过加强鼻内气味传递来改善嗅觉功能方面显示出初步的希望.
- 不同的原型可能对不同类型的嗅觉功能障碍和患者队伍有效.
- 这些发现表明,一种有效的非处方香味辅助剂有潜力解决嗅觉障碍.
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