单细胞与淋巴细胞比率与心血管疾病之间的关联:从NHANES数据的见解
Xiaowan Li1, Liyan Zhang1, Yingying Du1,2
1Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Diabetology & metabolic syndrome
|March 25, 2025
概括
单细胞与淋巴细胞比率 (MLR) 是心血管疾病 (CVD) 的更好的预测指标,而不是其他炎症标志物. 升高的MLR表明心脏病发作,中风和心力衰竭的风险增加.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球健康的重大负担.
- 确定可靠的炎症标志物对心血管疾病风险预测至关重要.
研究的目的:
- 研究单细胞与淋巴细胞比率 (MLR) 和各种心血管疾病 (CVD) 之间的相关性.
- 将MLR的预测性能与其他炎症指数进行比较.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (1999-2020年).
- 研究了MLR,SIRI,AISI,CAR和心血管疾病事件 (心脏病发作,心痛,心血管疾病,心血管疾病,中风) 之间的关系.
- 使用接收器操作特征 (ROC) 曲线来评估诊断能力.
主要成果:
- 在MLR和心血管疾病患病率之间观察到正面的非线性相关性.
- 较高的MLR水平与心血管衰竭,心血管疾病和中风的发病率增加有关.
- 与SIRI,AISI和CAR相比,MLR在预测心血管疾病及其亚型方面表现出更高的区分能力和准确性.
结论:
- 与SIRI,AISI和CAR相比,MLR作为预测心血管疾病及其特定事件的更有效的炎症指数.
- 升高的MLR和SIRI需要注意美国成年人潜在的心血管疾病风险.
- 建议进行进一步的纵向研究,以证实这些发现,因为横截面设计.
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