膜固和产生氧气的中介纳米传感剂,用于优化癌症免疫疗法
Qing Zhao1, Ye Han2, Wushuang Gong2
1Ultrasound Department of Obstetrics and Gynecology, Second Affiliated Hospital of Harbin Medical University, Surgeons' Hall, No.246. XuefuRoad, Nangang District, Harbin, Heilongjiang Province, 150086, P. R. China.
Advanced healthcare materials
|March 25, 2025
概括
这项研究引入了用于声动疗 (SDT) 的新型纳米粒子,通过克服瘤缺氧和改善药物输送来增强抗瘤免疫力,从而导致显著的瘤生长抑制.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 声动力学疗法 (SDT) 对癌症治疗有希望,但受到低氧瘤微环境 (TME) 和低效的声敏剂向限制.
- 在TME中增强免疫激活对于提高SDT疗效至关重要.
研究的目的:
- 开发用于Sonoimmunotherapy的先进纳米粒子,以克服TME的局限性并增强抗瘤免疫反应.
- 研究一种新型纳米粒子系统的治疗潜力,该系统结合了声动力学疗法和免疫检查点封锁.
主要方法:
- 巨细胞膜混合的膜融合性脂质体 (MFL) 封装着催化酶 (CAT) 和e6 (Ce6) 的工程 (CAT@MM-MFL-Ce6).
- 超声波刺激被用来触发反应性氧物种生成和热.
- 酶活性被利用来缓解瘤缺氧.
主要成果:
- 开发的纳米颗粒证明了瘤中的向积累和有效的细胞质中催化酶的输送.
- 超声波触发的SDT诱导热和增强局部氧气水平.
- 组合疗法逆转了免疫抑制性TME,抑制了原发性瘤生长,并在三阴性乳腺癌模型中减少了转移.
结论:
- 新型CAT@MM-MFL-Ce6纳米颗粒通过解决瘤缺氧和免疫抑制,为体内免疫疗法提供了一个有前途的战略.
- 这种方法代表了在为免疫冷瘤开发有效的组合性癌症疗法方面取得的重大进展.
更多相关视频
07:54Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
8.1K
09:02Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
Published on: September 27, 2024
2.4K
相关概念视频
01:27Tumor Immunotherapy
450
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
450
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K