相关实验视频
Updated: May 20, 2025

09:58
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
3.4K
脂质组成 人类大脑的多样性 白色物质的轨迹
Marina Zavolskova1, Dmitry Senko1, Maria Osetrova1
1Skolkovo Institute of Science and Technology, Moscow, Russia.
Journal of neurochemistry
|March 25, 2025
概括
这项研究使用空间脂管学绘制大脑脂质图,揭示了灰质,环束和大脑体中不同的分子概况. 这些发现提升了对大脑结构和功能的理解.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 分析化学 分析化学
背景情况:
- 人类大脑的结构组织是其功能的关键.
- 了解不同大脑区域的分子组成至关重要.
研究的目的:
- 为了对人类大脑部分进行空间脂管学分析.
- 为了确定灰质和两个白质区域 (束和体) 之间的脂质组成差异.
主要方法:
- 用于空间分析的矩阵辅助激光消耗/电离质谱成像 (MALDI-MSI).
- 超高性能液体染色学-并联质谱学 (UPLC-MS/MS) 用于详细的脂质分析.
- MALDI-MSI和UPLC-MS/MS数据之间的相关性分析.
主要成果:
- 在灰质和白质区域之间确定了脂质组成的差异.
- 在带束和体之间观察到明显的脂质配置.
- 特定的脂质类 (CL,PG,LPE) 区分了白质区域,而 (CL,DG,胆固醇) 区分了灰色和白质.
结论:
- 空间脂管学为人类大脑的分子结构提供了宝贵的见解.
- 这项研究增强了对大脑区域分子组成及其对功能影响的理解.
相关概念视频
Spinal Cord: Cross-sectional Anatomy
1.6K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray...
Gray Matter and its Components
Central to the gray...
1.6K
Membrane Lipids
20.8K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
20.8K
Anatomy of the Brain: Major Regions
3.3K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
3.3K
Cerebrum: Anatomical Overview II
1.4K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.4K
Neuron Structure
218.4K
Overview
218.4K

