乙醇生产能力对女性下尿路症状的影响
Chie Nakagawa1,2, Yoshiyuki Okada1,2, Miwa Shigeta1
1Department of Female Pelvic Health Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
The journal of obstetrics and gynaecology research
|March 25, 2025
概括
无法产生equol的日本女性患下尿路症状 (LUTS) 的风险更高. 这表明equol产量与雌性LUTS之间的潜在联系,需要进一步调查.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 下尿道症状 (LUTS) 影响许多女性,可能与荷尔蒙变化有关.
- 埃科尔是戴兹的代谢物,已显示出潜在的雌激素活性.
- 在女性中,EQUOL生产能力和LUTS之间的关系仍然未得到充分研究.
研究的目的:
- 调查女性下尿道症状 (LUTS) 与她们产卵能力之间的关联.
- 为了确定equol生产是否影响日本女性人口中LUTS的流行.
主要方法:
- 一项涉及217名年龄在20-75岁的日本女性的横截面研究.
- 参与者被分为两组:具有LUTS (n=95) 和没有LUTS (n=122) 的参与者.
- 用免疫染色学测量尿液中equol度,以评估equol生产能力 (≥1.0μM定义为阳性).
主要成果:
- 在28.4%的LUTS女性中,观察到equol的产生,而在没有LUTS的女性中,这一比例为52.5% (p=0.0004).
- 后勤回归分析表明,无法产生equol是LUTS的重要风险因素 (OR,2.21;p=0.0144).
- 这表明,受损的equol产量与LUTS的存在之间存在统计学上显著的相关性.
结论:
- 在女性中,Equol生产能力可能与下泌尿道症状有关.
- 需要进一步的干预研究来证实这种关联并探索因果关系.
- 未来的研究还应该检查特定的LUTS和equol生产之间的关系.
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