血克里特对质量控制参数的影响在血小板转化过程中
Svetlana Jović Lacković1, Sunita Delić Ćustendil1, Aida Žabić1
1Department for Collection of Blood and Blood Components, Polyclinic for Transfusion Medicine, University Clinical Centre Tuzla, Tuzla, Bosnia and Hercegovina.
概括
供体血红素会影响血小板分裂的持续时间和资源使用,但不会影响血小板产品的质量. 捐献者的血红素水平较高导致了更长的手术,但保持了高质量的血小板度,符合国际标准.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 阿菲雷西斯技术的技术
背景情况:
- 血小板分裂是采用细胞分离器收集血小板的重要程序.
- 来自阿费雷西斯的血小板缩剂提供了卓越的功能,活力和降低了感染风险.
- 捐赠者预捐血红素是影响非结局的关键因素.
研究的目的:
- 为了研究捐赠者预捐血红素对血小板转化产品质量控制参数的影响.
- 评估与供体血红素水平相关的不良事件的频率.
- 为了优化基于捐赠者的血小板转化程序.
主要方法:
- 从2022年1月到2023年12月的血小板转移手术的回顾性分析.
- 两组献血者之间的质量控制参数的比较:血红素<45%和血红素≥45%.
- 统计分析以确定血红素水平对程序结果的意义.
主要成果:
- 总共有116名捐赠者被分析 (73名Hct<45%,43名Hct≥45%).
- 较高的先献血红度 (≥45%) 与明显更高的总加工血液体积相关 (p<0.0001).
- 血小板转移的持续时间在具有较高血红素值 (p=0.003) 的捐赠者中显着更长.
结论:
- 捐赠者血红素显著影响血小板转移过程的持续时间和资源消耗.
- 血小板度的质量在很大程度上不受捐赠者的血红素水平的影响.
- 血小板产品的质量始终符合ISBT和AABB的推值,不论捐赠者的血红素.
相关概念视频
01:19Regulation of Metabolism
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
01:24Factors Affecting Erythropoiesis
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
01:29Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:28Bioreactor Controls-I
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...