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Updated: May 20, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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由两个基因集群编码的合作氧化反应使分子间循环添加级联能够形成美洛阿斯波哈拉辛

Pengkun Li1, Jie Meng1, Xiaotian Zhang1

  • 1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Angewandte Chemie (International ed. in English)
|March 25, 2025
PubMed
概括

研究人员发现了Aspergillus flavipes中meroaspochalasins (mAPOs) 的生物合成途径. 关键酶FlasF,FlasG,EpiC,EpiD和EpiG协调mAPO单体,二元体和三元体的形成.

关键词:
亚斯伯吉勒斯黄虫 (Aspergillus flavipes) 是一种植物.合作式的氧化解氧化技术.交叉路径的交叉路径.循环添加反应的反应梅罗亚斯波卡莱辛是一种有氧化物.

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