APOE ɛ4状态和血管负担对白质微观结构完整性的交互作用在老化中,有或没有神经认知能力下降
Srijan Konwar1, Riccardo Manca1,2, Matteo De Marco1
1Department of Life Sciences, Brunel University London, Uxbridge, UK.
Journal of Alzheimer's disease : JAD
|March 25, 2025
概括
阿波脂蛋白E ε4等位基因和血管问题相互作用,影响衰老和阿尔茨海默病中的白质完整性. 这种相互作用对大脑健康的影响比单独的任何一个因素都要大.
科学领域:
- 神经成像是一种神经成像.
- 遗传学 遗传学 是一个
- 血管健康 血管健康
背景情况:
- 阿波利波蛋白E (APOE) ε4基因基因是阿尔茨海默病 (AD) 的重要危险因素,降低了发病年龄.
- 混合病理,包括血管因素,在阿尔茨海默病患者中很常见.
- 白质 (WM) 完整性对认知功能至关重要,并受到衰老和神经退行性疾病的影响.
研究的目的:
- 调查APOE ε4基因型和血管并发症对白质 (WM) 微观结构的联合影响.
- 了解这些因素在老年人和患有早期阿尔茨海默氏症 (AD) 的个体中如何相互作用.
主要方法:
- 利用了来自VPH-DARE@IT数据集的195名参与者的数据.
- 用Framingham风险评分 (BMI版本) 将参与者分为低/高血管负担组.
- 采用基于路径的空间统计 (TBSS) 用于使用扩散指数进行详细的WM微结构分析.
主要成果:
- 与非载体相比,APOE ε4载体显示出不同的扩散模式 (较高的FA,较低的AxD,MD,RD).
- 较高的血管负担与WM完整性降低有关 (较低的FA,较高的AxD,MD,RD).
- 一个显著的相互作用表明,APOE ε4和高血管负担的组合对WM完整性有明显的影响,特别是在特定的大脑半球.
结论:
- 在APOE基因型和血管并发症之间存在对WM完整性在衰老和早期AD的交互效应.
- 由于遗传风险 (APOE ε4) 和血管风险因素的联合存在,WM的完整性受到损害.
- 这些发现突出了遗传和血管因素在大脑衰老和AD病变发生过程中的复杂相互作用.
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