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以EEG光谱为指导的个性化rTMS在PTSD中与同时发生的精神疾病:一个案例系列

Kavya Mohankumar^1,2, Siddharth Karthikeya^1,3, Shaurya Mahajan^1,4

¹Division of Clinical Neuromodulation Research, Karma Doctors, Palm Springs, CA, USA.

Acta scientific neurology

|March 25, 2025

概括

在一系列病例中,个性化的重复性跨体磁性刺激 (PrTMS) 改善了创伤后应激障碍 (PTSD) 症状. 患者的PTSD,焦虑和抑郁症显著减少,睡眠改善,表明PrTMS.

科学领域:

神经学神经学
精神病学是一个精神病学.
神经科学是一个神经科学.

背景情况:

创伤后应激障碍 (PTSD) 是一种使人虚弱的疾病,通常需要新的治疗方法.
个性化的重复性跨体磁性刺激 (PrTMS) 使用个性化协议进行神经调节.
通过光谱脑电图 (EEG) 优化α脑波活动是一个潜在的治疗目标.

研究的目的:

在两个被诊断患有PTSD的患者中调查PrTMS的治疗结果.
通过定量评级尺度和光谱EEGα波优化来评估PrTMS的有效性.

主要方法:

两名患有PTSD的患者接受了PrTMS治疗.
治疗方案由标准化评分尺度和每周频谱EEG测量提供信息.
使用PCL-5,GAD-7,PHQ-9和SCI问卷追踪症状严重程度.

主要成果:

在所有心理测量评估中都观察到显著的症状改善.
创伤后应激障碍检查清单DSM-5 (PCL-5) 评分在第4周平均下降了20.5分.
综合焦虑症7项量表 (GAD-7) 和患者健康问卷-9 (PHQ-9) 的分数在第7周分别下降了7分和8.5分.
睡眠状况指标 (SCI) 评分在7周治疗期结束时增加了6分.

结论:

在这种案例系列中,以光谱EEG为指导的PrTMS证明了对PTSD症状的治疗益处.
这些发现支持了关于EEG指导的PTSD个性化神经调节的先前研究.
需要进一步的研究来确定PrTMS对PTSD的长期疗效和通用性.

关键词:

阿尔法脑波活动神经调节是一种神经调节.PCL-5 (对于DSM-5的创伤后应激障碍症状严重性检查清单)创伤后应激障碍 (PTSD) 是一种创伤后应激障碍.个性化的重复性跨头骨磁性刺激 (PrTMS®)重复性跨膜磁性刺激 (rTMS) 是一种方法.频谱EEG电磁波的使用情况谱电脑电图 (ESG) 是一种光谱电脑电图.

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