心力衰竭管理的创新:尖端生物标志物和多omics集成的作用
Jose Mesquita Bastos1,2, Beatriz Colaço1,2, Rui Baptista3,4,5,6
1Department of Medical Sciences, Institute of Biomedicine iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.
Journal of molecular and cellular cardiology plus
|March 25, 2025
概括
新的多组生物标志物显示出改善心力衰竭 (HF) 诊断和治疗的前景. 整合这些先进的工具可以个性化护理,提高患者的治疗结果,克服传统方法的局限性.
科学领域:
- 心血管医学 心血管医学
- 生物标志物发现发现
- 基因组学和蛋白质组学
背景情况:
- 心力衰竭 (HF) 因其异质性而带来诊断和治疗方面的挑战.
- 像BNP这样的传统生物标志物对于复杂的HF表型是不够的,包括具有保留射出分数 (HFpEF) 的HF.
- 新兴的多omics技术为了解和管理高频提供了新的途径.
研究的目的:
- 审查将新型多组生物标志物纳入HF管理的临床实践的整合.
- 突出创新的生物标志物的好处,例如改善诊断准确性和风险分层.
- 探索针对个性化HF治疗的多omics方法的潜力.
主要方法:
- 综述了最近在多组技术 (脂组学,代谢学,蛋白质学) 中取得的进展.
- 对包括无细胞DNA (cfDNA),microRNAs (miRNAs),ST2和galectin-3在内的新生物标志物的分析.
- 探索多omics数据以确定HF机制,如线粒体功能障碍,炎症和纤维化.
主要成果:
- 创新的生物标志物显示出在高频中提高诊断准确性和非侵入性监测的潜力.
- 多omics方法可以改进HF表型,并确定针对性治疗的途径.
- 与炎症,纤维化和线粒体功能障碍相关的生物标志物正在出现.
结论:
- 一个集成的,基于多个学科的模型对于推进高频管理至关重要.
- 研究人员,临床医生和决策者之间的合作对于临床翻译至关重要.
- 多omics方法有望重新定义HF护理,改善患者的治疗结果和医疗保健的可持续性.
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